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FORKHEAD IN RHABDOMYOSARCOMA PROTEIN
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DeCS
Descriptor
English
:
Forkhead Box Protein O1
Descriptor
Spanish
:
Proteína Forkhead Box O1
Descriptor
Portuguese
:
Proteína Forkhead Box O1
Synonyms
English
:
FOXO1 Protein
Forkhead in Rhabdomyosarcoma Protein
Tree Number:
D12.776.260.950.249.250
D12.776.930.977.249.250
Definition
English
:
A forkhead box transcription factor that is a major target of
INSULIN
signaling and regulator of metabolic
homeostasis
in response to
OXIDATIVE STRESS
. It binds to the
insulin
RESPONSE ELEMENT (IRE) and the related Daf-16
family
binding element (DBE). Its activity is suppressed by
insulin
and it also regulates
OSTEOBLAST
proliferation, controls bone mass, and skeletal regulation of
GLUCOSE
metabolism
. It promotes
GLUCONEOGENESIS
in
HEPATOCYTES
and regulates
gene expression
in
ADIPOSE TISSUE
. It is also an important
CELL DEATH
regulator. Chromosomal aberrations involving the FOXO1 gene occur in
RHABDOMYOSARCOMA.
History Note
English
:
2017
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
56616
Unique Identifier:
D000071161
Occurrence in VHL
:
Similar:
DeCS